A case of Darier-Roussy sarcoidosis
Keywords:
Subcutaneous sarcoidosis, Tuberculosis, Interferon-γ release assay (IGRA)Abstract
Subcutaneous sarcoidosis, a rare form of cutaneous sarcoidosis, is seen in approximately 4.3-12.1% of patients with systemic sarcoidosis. These lesions are often associated with less severe systemic disease and usually appear at the beginning of the disease. The present study discusses an unusual case of subcutaneous sarcoidosis with interferon-γ release assay (IGRA) positivity. The case report highlights the increased chances of misdiagnosis of Darier-Roussy sarcoidosis as tuberculosis based on positive IGRA, especially in countries with increased prevalence of TB.
References
Yanardağ H, Pamuk ON, Karayel T. Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respir Med. 2003 Aug;97(8):978–82.
Morimoto T, Azuma A, Abe S, Usuki J, Kudoh S, Sugisaki K, et al. Epidemiology of sarcoidosis in Japan. Eur Respir J. 2008 Feb;31(2):372–9.
Ahmed I, Harshad SR. Subcutaneous sarcoidosis: is it a specific subset of cutaneous sarcoidosis frequently associated with systemic disease? J Am Acad Dermatol. 2006 Jan;54(1):55–60.
Heller M, Soldano AC. Sarcoidosis with subcutaneous lesions. Dermatol Online J. 2008;14(5):1.
Gupta D, Agarwal R, Aggarwal AN, Jindal SK. Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis. Eur Respir J. 2007 Sep;30(3):508–16.
Gupta D, Kumar S, Aggarwal AN, Verma I, Agarwal R. Interferon gamma release assay (QuantiFERON-TB Gold In Tube) in patients of sarcoidosis from a population with high prevalence of tuberculosis infection. Sarcoidosis Vasc Diffuse Lung Dis Off J WASOG World Assoc Sarcoidosis Granulomatous Disord. 2011 Oct;28(2):95–101.
Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007 Nov 22;357(21):2153–65.