A study of clinical profile in female spondyloarthropathy
DOI:
https://doi.org/10.15305/ijrci/v7i1/317Abstract
Objective: To assess the clinical features of SpA including BATH indices and to compare clinical data of male and female spondyloarthropathy patients.
Methods: The study included male and female patients (60 each) fulfilling the European Spondyloarthropathy Study Group (ESSG) or assessment of ankylosing spondylitis (ASAS) criteria for SpA and the CASPER criteria for PsA or the modified New York criteria for AS. The subjects completed initial clinical evaluation and radiological and laboratory assessment.
Results: The mean age of presentation was found to be higher in females (34.6± 9.6 years). Backache was the most common features identified in both the groups. Peripheral arthritis was present in 51.7% of total patients (56.7% males and 46.7% females). Asymmetrical lower limb arthritis was found to be more predominant; however, 10% of the patients reported involvement of wrist. Psoriasis and inflammatory bowel disease, and uveitis were noted in 13 (7 males and 6 females), three (1 male and 2 females) and 14 patients (9 males and 5 females) respectively. Dorsal and neck pain were frequently prevalent among the patients.
Conclusion: Though the severity of symptoms and disability are comparable across both the genders, females have increasingly been diagnosed with SpA. Most common symptom of presentation is low back pain followed by gluteal pain. Peripheral arthritis, predominantly lower limb oligoarthritis is common in Indian population when compared to their western counterparts.
References
Goldmann L., Scafer AI, Goldman’s Cecil Medicine, 24th ed., New York: Elsevier; 2012. Chapter 273, Spondyloarthropathy; p.1690-1697
Gorman JD, Sack KE, Davis JC. Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med [Internet]. 2002 May 2 [cited 2015 Jun 15];346(18):1349–56.
Braun J, Sieper J. Ankylosing spondylitis. Lancet [Internet]. 2007 Apr 21 [cited 2015 Jun 16];369(9570):1379–90
Rudwaleit M, Listing J, Brandt J, Braun J, Sieper J. Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis. Ann Rheum Dis. 2004;63(6):665–70.
Prasad P, Singh RP. Ankylosing spondylitis in tribal belt of Chhotanagpur region. J Indian Med Assoc [Internet]. 1982 Apr 1 [cited 2015 Jun 16];78(7):108–12.
Khan MA. Ankylosing spondylitis and HLA-B27 in Punjabis. Lancet [Internet]. 1977 Sep 3 [cited 2015 Jun 16];2(8036):504.
Prasad P, Singh RP. Ankylosing spondylitis in tribal belt of Chhotanagpur region. J Indian Med Assoc [Internet]. 1982 Apr 1 [cited 2015 Jun 16];78(7):108–12
Prakash S, Mehra NK, Bhargava S, Vaidya MC, Malaviya AN. Ankylosing spondylitis in North India: a clinical and immunogenetic study. Ann Rheum Dis [Internet]. 1984 Jun [cited 2015 Jun 16];43(3):381–5.
Achuthan K, Porkodi R, Ramakrishnan S, Krishnamurthy V, Madhavan R, Parthiban M, et al. Pattern of rheumatic diseases in south India. V. Ankylosing spondylitis. A clinical and radiological study. J Assoc Physicians India [Internet]. 1990 Oct [cited 2015 Jun 16];38(10):774–6.
Dougados M, van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A, et al. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum [Internet]. 1991 Oct [cited 2015 May 19];34(10):1218–27.
Feldtkeller E, Khan MA, van der Heijde D, van der Linden S, Braun J. Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int [Internet]. 2003 Mar [cited 2015 May 18];23(2):61–6.
Carette S, Graham D, Little H, Rubenstein J, Rosen P. The natural disease course of ankylosing spondylitis. Arthritis Rheum [Internet]. 1983 Feb [cited 2015 Jun 24];26(2):186–90.
Aggarwal R, Malaviya AN. Clinical characteristics of patients with ankylosing spondylitis in India. Clin Rheumatol [Internet]. 2009 Oct [cited 2015 Jun 24];28(10):1199–205.
Zink A. The national database of the German Collaborative Arthritis Centres: I. Structure, aims, and patients. Ann Rheum Dis [Internet]. 2001 Mar 1 [cited 2015 May 28];60(3):199–206
Feldtkeller E, Braun J. Impact of sex on inheritance of ankylosing spondylitis. Lancet (London, England) [Internet]. 2000 Mar 25 [cited 2015 Jun 24];355(9209):1096–7; author reply 1098
Aggarwal R, Malaviya AN. Diagnosis delay in patients with ankylosing spondylitis: factors and outcomes--an Indian perspective. Clin Rheumatol [Internet]. 2009 Mar [cited 2015 Jun 16];28(3):327–31.
Roussou E, Sultana S. Spondyloarthritis in women: differences in disease onset, clinical presentation, and Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI) between men and women with spondyloarthritides. Clin Rheumatol [Internet]. 2011 Jan [cited 2015 Jun 24];30(1):121–7.
Firestein G S., Budd R C, Gabriel S E, O’Dell J.R., MnInnes I.B., Kelly’s Textbook of Rheumatology, 9th ed.,Philadelphia: Elsevier; 2013. Chapter 75, Ankylosing Spondylitis; p.1202-1220.
Singh G, Lawrence A, Agarwal V, Misra R, Aggarwal A. Higher prevalence of extra-articular manifestations in ankylosing spondylitis with peripheral arthritis. J Clin Rheumatol [Internet]. 2008 Oct [cited 2015 Jun 24];14(5):264–6.
Linder R, Hoffmann A, Brunner R. Prevalence of the spondyloarthritides in patients with uveitis. J Rheumatol [Internet]. 2004 Nov 1 [cited 2015 Jun 23];31(11):2226–9.
Kanga U, Mehra NK, Larrea CL, Lardy NM, Kumar A, Feltkamp TE. Seronegative spondyloarthropathies and HLA-B27 subtyes: a study in Asian Indians. Clin Rheumatol [Internet]. 1996 Jan [cited 2015 Jun 24];15 Suppl 1:13–8.
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