Occurrence of disabling myopathy secondary to hypovitaminosis D
DOI:
https://doi.org/10.15305/ijrci/v1i1/31Keywords:
Vitamin D, Proximal myopathy, Myotonia dystrophica, PTH, ALPAbstract
We report a case of severe proximal muscle weakness caused by vitamin D deficiency. Hypovitaminosis D myopathy (HDM) is often misdiagnosed, as the symptoms are non-specific. However, the disease is easily treatable and complete recovery is possible if diagnosed on time.
References
Ziambaras K, Dagogo-Jack S. Reversible muscle weakness in patients with vitamin D deficiency. West J Med.1997 December;167(6):435-439.
Prineas, JW, Mason AS, Henson RA. 1965. Myopathy in metabolic bone disease. Br. Med. J. 1965 Apr 17;1(5441):1034–6.
Schott GD, Wills MR. Muscle weakness in osteomalacia. Lancet. 1976 Mar 20;1(7960):626–9.
Kennel KA, Drake MT, Hurley DL. Vitamin D Deficiency in Adults: When to Test and How to Treat. Mayo Clin Proc. 2010 Aug;85(8):752–8.
DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 2004 Dec;80(6 Suppl):1689S–96S.
Boland R. Role of Vitamin D in Skeletal Muscle Function. Endocrine Reviews. 1986 Nov 1;7(4):434–48.
Myotonic dystrophy [Internet]. Yale school of Medicine. [updated 2013 February 14]. Available from: http://medicine.yale.edu/neurology/divisions/neuromuscular/md.aspx
Snijder MB, Van Schoor NM, Pluijm SMF, Van Dam RM, Visser M, Lips P. Vitamin D status in relation to one-year risk of recurrent falling in older men and women. J. Clin. Endocrinol. Metab. 2006 Aug;91(8):2980–5.
Yoshikawa S, Nakamura T, Tanabe H, Imamura T. Osteomalacic myopathy. Endocrinol. Jpn. 1979 Jun;26(Suppl):65–72.
Holick MF. Vitamin D Deficiency.. N Engl J Med. 2007;357:266-281.
Harinarayan CV, Joshi SR. Vitamin D status in India--its implications and remedial measures. J Assoc Physicians India. 2009 Jan;57:40–8.
Garber AJ. Effects of parathyroid hormone on skeletal muscle protein and amino acid metabolism in the rat. J. Clin. Invest. 1983 Jun;71(6):1806–21.
Smogorzewski M, Piskorska G, Borum PR, Massry SG. Chronic renal failure, parathyroid hormone and fatty acids oxidation in skeletal muscle. Kidney Int. 1988 Feb;33(2):555–60.
Pepper KJ, Judd SE, Nanes MS, Tangpricha V. Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocr Pract. 2009 Mar;15(2):95–103.
Heaney RP. The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol.2005 Oct;97:13-19.
Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Andersen H, et al. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif. Tissue Int. 2000 Jun;66(6):419–24.
Chandra SR, Shenoy RK, Karthikeyan, Suresh K, Chithra P, Annapoorni CSV. Two cases of a rare treatable limb girdle muscle disease. J Assoc Physicians India. 2011 May;59:321–5.
Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin. Proc. 2006 Mar;81(3):353–73.
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin. Proc. 2003 Dec;78(12):1463–70.
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