Benign Joint Hypermobility Syndrome – not so ‘Benign’
DOI:
https://doi.org/10.15305/ijrci/v3i1/140Keywords:
Benign Joint Hypermobility Syndrome, Secondary osteoarthritis, Irritable bowel syndrome.Abstract
Benign joint hypermobility syndrome (BJHS) was earlier considered as a mild or trivial entity, but nowadays it is reported as a multisystem hereditary connective tissue disorder with serious morbidities. In fact, the term ‘Benign’ has been removed, renaming the disease as ‘Joint Hypermobility Syndrome’ (JHS). In addition to the well-known musculoskeletal consequences of joint pain and instability, it can cause chronic widespread pain, gastrointestinal dysmotility, anxiety, phobic states and dysautonomia. We present here the case of a 53-year-old lady who presented with history of irritable bowel syndrome, elbow dislocation, repeated knee injuries, and instability resulting in severe secondary osteoarthritis (OA).
References
Kirk JH, Ansell BA, Bywaters EGL. The hypermobility syndrome. Ann Rheum Dis 1967;26:419-25.
Grahame R, Bird HA, Child A, et al. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 2000;27:1777-9.
Gratacós M, Nadal M, Martin-Santos R, et al. A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell 2001;106:367-79.
Farmer AD, Zarate-Lopez N, Mohammed SD, et al. Functional gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link? [abstract 217]. Rheumatology 2009;48.
Gazit Y, Nahir AM, Grahame R, Jacob G. Dysautonomia in the hypermobility syndrome. Am J Med 2003;115:33-40.
Hakim AJ, Grahame R. Non-musculoskeletal symptoms in joint hypermobility syndrome: indirect evidence for autonomic dysfunction. Rheumatology 2004;43: 1194-5.
Additional Files
Published
Issue
Section
License
Copyright for articles published in this journal is retained by the authors, with first publication rights granted to the ‘Internet Journal of Rheumatology and Clinical Immunology’. All the published content, except where otherwise noted, is licensed under Creative Commons license (CC-BY).
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) after the publication of the manuscript in IJRCI, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
