Angiopoietin-like protein 2 mediates vasculopathy-driven fibrogenesis in a mouse model of skin fibrosis

Authors

  • Dyuti Saha Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Sujaya Thannimangalath Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Neha Pincha Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Ravikiran Annadorai Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Sunny Kataria Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Binita Dam Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Ankita Hiwale Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Praveen Vemula Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India
  • Colin Jamora Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bengaluru, India

DOI:

https://doi.org/10.15305/ijir.v7i1.386

Abstract

Fibrosis is a pathological condition wherein excessive deposition of extracellular matrix components leads to tissue hardening and loss of function. Though fibrosis contributes to ~40% of deaths worldwide, the lack of effective treatments highlights the need for a molecular understanding of fibrogenesis. Vasculature abnormalities are a foundational cause of fibrotic disorders such as the skin fibrotic disease scleroderma, however the underlying mechanisms are largely unknown.

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Published

15-11-2023

Issue

Vol. 7 No. 1 (2023)

Section

Abstracts

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