Nuclear Receptor Co-repressor NCoR1 governs immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

Authors

  • Kaushik Sen India Institute of Life Sciences, Bhubaneshwar, Odisha-751023
  • Rashmirekha Pati
  • Atimukta Jha
  • Gyan Prakash Mishra Prakash Mishra
  • Subhasish Prusty
  • Shweta Chaudhary
  • Swati Swetalika
  • Sreeparna Podder
  • Aishwarya Sen
  • Mamuni Swain
  • Ranjan Nanda
  • Sunil K. Raghav

DOI:

https://doi.org/10.15305/ijir.v7i1.372

Abstract

Dendritic cells (DCs) undergo rapid metabolic reprogramming events to induce signal-specific immune responses. The transcriptional control of energy metabolism in tolerogenic-DCs remains elusive. We have recently reported that NCoR1 ablation in DCs leads to immune tolerance by altering the balance of naive T helper cells towards T-regs. Here, comprehensive metabolic profiling of these tolerogenic DCs identified that they meet their anabolic requirements through enhanced glycolysis and OxPhos, supported by FAO-driven oxygen consumption.

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Published

31-01-2023

Issue

Vol. 7 No. 1 (2023)

Section

Abstracts

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